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Ancestral Sequence Reconstruction: Methods and Applications

Straub, Kristina (2019) Ancestral Sequence Reconstruction: Methods and Applications. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Sep 2019 08:23

Abstract (English)

A major goal in the study of molecular evolution is to elucidate properties of ancestral proteins and to understand their adaption induced by changes in the environment. Due to the lack of macromolecular fossils, ancestral sequence reconstruction (ASR) is the only alternative to deduce sequences for evolutionary precursors of extant proteins. Within the last years, ancestral proteins were ...

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Translation of the abstract (German)

Ein Hauptziel bei der Erforschung der molekularen Evolution ist es, die Eigenschaften der anzestralen Proteine ​​aufzuklären und deren Anpassung durch Veränderungen in der Umwelt zu verstehen. Aufgrund des Mangels an makromolekularen Fossilien ist die Rekonstruktion anzestraler Sequenzen (ASR) die einzige Alternative, um Sequenzen für evolutionäre Vorläufer von vorhandenen Proteinen abzuleiten. ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:9 September 2019
Referee:Prof. Dr. Rainer Merkl
Date of exam:31 August 2018
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Keywords:anzestrale Sequenzrekonstruktion; Phylogenie; Proteindesign; Proteinevolution
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37686
Owner only: item control page

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