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Ancestral Sequence Reconstruction: Methods and Applications

URN to cite this document:
urn:nbn:de:bvb:355-epub-376861
DOI to cite this document:
10.5283/epub.37686
Straub, Kristina
Date of publication of this fulltext: 09 Sep 2019 08:23


Abstract (English)

A major goal in the study of molecular evolution is to elucidate properties of ancestral proteins and to understand their adaption induced by changes in the environment. Due to the lack of macromolecular fossils, ancestral sequence reconstruction (ASR) is the only alternative to deduce sequences for evolutionary precursors of extant proteins. Within the last years, ancestral proteins were ...

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Translation of the abstract (German)

Ein Hauptziel bei der Erforschung der molekularen Evolution ist es, die Eigenschaften der anzestralen Proteine ​​aufzuklären und deren Anpassung durch Veränderungen in der Umwelt zu verstehen. Aufgrund des Mangels an makromolekularen Fossilien ist die Rekonstruktion anzestraler Sequenzen (ASR) die einzige Alternative, um Sequenzen für evolutionäre Vorläufer von vorhandenen Proteinen abzuleiten. ...

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