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Determination of Total and Free Ceftolozane and Tazobactam in Human Plasma and Interstitial Fluid by HPLC-UV

Kratzer, Alexander, Schießer, Selina, Matzneller, Peter, Wulkersdorfer, Beatrix, Zeitlinger, Markus, Schlossmann, Jens, Kees, Frieder and Dorn, Christoph (2018) Determination of Total and Free Ceftolozane and Tazobactam in Human Plasma and Interstitial Fluid by HPLC-UV. Journal of Pharmaceutical and Biomedical Analysis.

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Other URL: http://doi.org/10.1016/j.jpba.2018.09.044


Abstract

Ceftolozane/tazobactam is a new cephalosporin/beta-lactamase inhibitor combination. An HPLC-UV method is described for the determination of total and free ceftolozane and tazobactam in human plasma and in microdialysate of subcutaneous tissue, respectively. Separation was performed using a reversed-phase column with phosphate buffer/acetonitrile as eluent and photometric detection at 260 nm ...

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Item type:Article
Date:24 September 2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
10.1016/j.jpba.2018.09.044DOI
Keywords:cephalosporin; beta-lactamase inhibitor; plasma protein binding; tissue; ultrafiltration; microdialysis
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37769
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