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Determination of Total and Free Ceftolozane and Tazobactam in Human Plasma and Interstitial Fluid by HPLC-UV

Kratzer, Alexander ; Schießer, Selina ; Matzneller, Peter ; Wulkersdorfer, Beatrix ; Zeitlinger, Markus ; Schlossmann, Jens ; Kees, Frieder ; Dorn, Christoph


Ceftolozane/tazobactam is a new cephalosporin/beta-lactamase inhibitor combination. An HPLC-UV method is described for the determination of total and free ceftolozane and tazobactam in human plasma and in microdialysate of subcutaneous tissue, respectively. Separation was performed using a reversed-phase column with phosphate buffer/acetonitrile as eluent and photometric detection at 260 nm ...


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