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Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR

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Heinrich, Paul ; Kohler, Christian ; Ellmann, Lisa ; Kuerner, Paul ; Spang, Rainer ; Oefner, Peter J. ; Dettmer, Katja
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Jan 2019 14:09


Experiments with stable isotope tracers such as C-13 and N-15 are increasingly used to gain insights into metabolism. However, mass spectrometric measurements of stable isotope labeling experiments should be corrected for the presence of naturally occurring stable isotopes and for impurities of the tracer substrate. Here, we analyzed the effect that such correction has on the data: omitting ...


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