Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR

URN to cite this document:: urn:nbn:de:bvb:355-epub-381682
DOI to cite this document:: 10.5283/epub.38168

Heinrich, Paul ; Kohler, Christian

; Ellmann, Lisa ; Kuerner, Paul ; Spang, Rainer ; Oefner, Peter J.

; Dettmer, Katja

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Date of publication of this fulltext: 08 Jan 2019 14:09

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Abstract

Experiments with stable isotope tracers such as C-13 and N-15 are increasingly used to gain insights into metabolism. However, mass spectrometric measurements of stable isotope labeling experiments should be corrected for the presence of naturally occurring stable isotopes and for impurities of the tracer substrate. Here, we analyzed the effect that such correction has on the data: omitting ...