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Photochromic peptidic NPY Y4-receptor ligands

Lachmann, Daniel ; Konieczny, Adam ; Keller, Max ; König, Burkhard



Abstract

The neuropeptide Y (NPY) Y4 receptor is a G protein coupled receptor, which is targeted by pancreatic polypeptide, a homologue of NPY. Selective Y4R agonists were suggested as potential therapeutics for the treatment of obesity. Highly potent dimeric peptidic Y4R agonists, constituted of two pentapeptide moieties connected through an aliphatic linker, represent an interesting class of Y4R ...

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