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Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics

Paulzen, Michael, Schoretsanitis, Georgios , Stegmann, Benedikt, Hiemke, Christoph, Gründer, Gerhard, Schruers, Koen R.J., Walther, Sebastian , Lammertz, Sarah E. and Haen, Ekkehard (2017) Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics. Progress in Neuro-Psychopharmacology and Biological Psychiatry 76, pp. 101-106.

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Other URL: http://doi.org/10.1016/j.pnpbp.2017.03.002


Abstract

Objectives: To investigate in vivo the effect of low-potency antipsychotics on metabolism of risperidone (RIS). Methods: A therapeutic drug monitoring database containing plasma concentrations of RIS and its metabolite 9-OH-RIS of 1584 patients was analyzed. Five groups were compared; a risperidone group (n = 842) and four co-medication groups; a group co-medicated with chlorprothixene (n = 67), ...

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Item type:Article
Date:2017
Institutions:Psychology and Pedagogy > Institut für Psychologie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1016/j.pnpbp.2017.03.002DOI
Keywords:CYTOCHROME-P450 2D6; LEVOMEPROMAZINE; SCHIZOPHRENIA; MELPERONE; METABOLISM; CYP2D6; 9-HYDROXYRISPERIDONE; HALOPERIDOL; QUETIAPINE; INHIBITOR; Antipsychotics; Risperidone; Psychopharmacology; Pharmacokinetics; Therapeutic drug monitoring
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38904
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