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Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics

Paulzen, Michael ; Schoretsanitis, Georgios ; Stegmann, Benedikt ; Hiemke, Christoph ; Gründer, Gerhard ; Schruers, Koen R.J. ; Walther, Sebastian ; Lammertz, Sarah E. ; Haen, Ekkehard



Abstract

Objectives: To investigate in vivo the effect of low-potency antipsychotics on metabolism of risperidone (RIS). Methods: A therapeutic drug monitoring database containing plasma concentrations of RIS and its metabolite 9-OH-RIS of 1584 patients was analyzed. Five groups were compared; a risperidone group (n = 842) and four co-medication groups; a group co-medicated with chlorprothixene (n = 67), ...

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