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Garcke, Harald ; Lam, Kei Fong

Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport

Garcke, Harald and Lam, Kei Fong (2017) Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport. European Journal of Applied Mathematics 28 (02), pp. 284-316.

Date of publication of this fulltext: 20 Mar 2019 12:59
Article
DOI to cite this document: 10.5283/epub.39156


Abstract

We consider a diffuse interface model for tumour growth consisting of a Cahn-Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. ...

We consider a diffuse interface model for tumour growth consisting of a Cahn-Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. We establish well-posedness results for the tumour model and a variant with a quasi-static nutrient. It will turn out that the presence of the source terms in the Cahn-Hilliard equation leads to new difficulties when one aims to derive a priori estimates. However, we are able to prove continuous dependence on initial and boundary data for the chemical potential and for the order parameter in strong norms.



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Details

Item typeArticle
Journal or Publication TitleEuropean Journal of Applied Mathematics
Publisher:CAMBRIDGE UNIV PRESS
Place of Publication:NEW YORK
Volume:28
Number of Issue or Book Chapter:02
Page Range:pp. 284-316
Date2017
Additional Information (public)OA-Komponente aus Allianzlizenz
InstitutionsMathematics > Prof. Dr. Harald Garcke
Identification Number
ValueType
10.1017/S0956792516000292DOI
KeywordsDIFFUSE INTERFACE MODEL; LONG-TIME BEHAVIOR; HELE-SHAW CELL; MIXTURE MODEL; RECONNECTION; SIMULATION; PINCHOFF; Tumour growth; phase field model; Cahn-Hilliard equation; reaction-diffusion equations; chemotaxis; weak solutions; well-posedness
Dewey Decimal Classification500 Science > 510 Mathematics
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-391568
Item ID39156

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