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Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport
Garcke, Harald and Lam, Kei Fong
(2017)
Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport.
European Journal of Applied Mathematics 28 (02), pp. 284-316.
Date of publication of this fulltext: 20 Mar 2019 12:59
Article
DOI to cite this document: 10.5283/epub.39156
Abstract
We consider a diffuse interface model for tumour growth consisting of a Cahn-Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. ...
We consider a diffuse interface model for tumour growth consisting of a Cahn-Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. We establish well-posedness results for the tumour model and a variant with a quasi-static nutrient. It will turn out that the presence of the source terms in the Cahn-Hilliard equation leads to new difficulties when one aims to derive a priori estimates. However, we are able to prove continuous dependence on initial and boundary data for the chemical potential and for the order parameter in strong norms.
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| Item type | Article | ||||
| Journal or Publication Title | European Journal of Applied Mathematics | ||||
| Publisher: | CAMBRIDGE UNIV PRESS | ||||
|---|---|---|---|---|---|
| Place of Publication: | NEW YORK | ||||
| Volume: | 28 | ||||
| Number of Issue or Book Chapter: | 02 | ||||
| Page Range: | pp. 284-316 | ||||
| Date | 2017 | ||||
| Additional Information (public) | OA-Komponente aus Allianzlizenz | ||||
| Institutions | Mathematics > Prof. Dr. Harald Garcke | ||||
| Identification Number |
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| Keywords | DIFFUSE INTERFACE MODEL; LONG-TIME BEHAVIOR; HELE-SHAW CELL; MIXTURE MODEL; RECONNECTION; SIMULATION; PINCHOFF; Tumour growth; phase field model; Cahn-Hilliard equation; reaction-diffusion equations; chemotaxis; weak solutions; well-posedness | ||||
| Dewey Decimal Classification | 500 Science > 510 Mathematics | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-391568 | ||||
| Item ID | 39156 |
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