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Effect of smoking on risperidone pharmacokinetics – A multifactorial approach to better predict the influence on drug metabolism

Schoretsanitis, Georgios ; Haen, Ekkehard ; Stegmann, Benedikt ; Hiemke, Christoph ; Gründer, Gerhard ; Paulzen, Michael


Purpose: To disentangle an association between tobacco smoking, smoking habits and pharmacokinetic patterns such as plasma concentrations of risperidone (RIS), its active metabolite 9-hydroxyrisperidone (9-OH-RIS) and the active moiety, AM, (RIS + 9-OH-RIS) in a naturalistic sample. Methods: Plasma concentrations, dose adjusted plasma concentrations (C/D) of RIS, 9-OH-RIS and AM in patients out ...


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