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Intracellular availability of poorly soluble drugs from lipid nanocapsules

Bohley, Marilena ; Haunberger, Alexandra ; Göpferich, Achim



Abstract

Lipid nanocapsules (LNCs) are extensively used as drug carrier systems, due to their small size distribution, biocompatibility and ease of preparation. They are especially useful for lipophilic drugs to overcome physicochemical constraints that limit their efficacy, such as low solubility in aqueous media. The aim of this work was to investigate the relationship between the intracellular ...

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