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Intracellular availability of poorly soluble drugs from lipid nanocapsules

Bohley, Marilena, Haunberger, Alexandra and Göpferich, Achim (2019) Intracellular availability of poorly soluble drugs from lipid nanocapsules. European Journal of Pharmaceutics and Biopharmaceutics 139, pp. 23-32.

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Abstract

Lipid nanocapsules (LNCs) are extensively used as drug carrier systems, due to their small size distribution, biocompatibility and ease of preparation. They are especially useful for lipophilic drugs to overcome physicochemical constraints that limit their efficacy, such as low solubility in aqueous media. The aim of this work was to investigate the relationship between the intracellular ...

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Item type:Article
Date:2019
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejpb.2019.03.007DOI
Keywords:ipid nanocapsules, Intracellular availability, Poorly soluble drugs, Cyclosporin A, Itraconazole, Neovascular ocular diseases
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39776
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