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Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors

Gergs, U. ; Bernhardt, Günther ; Buchwalow, I. B. ; Edler, H. ; Fröba, J. ; Keller, Max ; Kirchhefer, U. ; Köhler, F. ; Mißlinger, N. ; Wache, H. ; Neumann, J.


In an integrative approach, we studied the role of histamine H(2 )receptors in the mouse heart. We noted that histamine, added cumulatively to the organ bath, failed to affect the force of contraction in left atrial preparations and did not change spontaneous heart rate in right atrial preparations from wild-type mice. By contrast, in the same preparations from mice that overexpressed the human ...


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