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Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial

Dorn, Christoph ; Petroff, David ; Neumann, Nancy ; Kratzer, Alexander ; El-Najjar, Nahed ; Dietrich, Arne ; Kloft, Charlotte ; Zeitlinger, Markus ; Kees, Martin ; Kees, Frieder ; Wrigge, Hermann ; Simon, Philipp


Objectives: To assess the pharmacokinetics and tissue penetration of fosfomycin in obese and non-obese surgical patients. Methods: Fifteen obese patients undergoing bariatric surgery and 15 non-obese patients undergoing major intra-abdominal surgery received an intravenous single short infusion of 8 g of fosfomycin. Fosfomycin concentrations were determined by LC-MS/MS in plasma and ...


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