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Regulation of the actin cytoskeleton in podocytes by the transcription factor LMX1B

URN to cite this document:
urn:nbn:de:bvb:355-epub-405077
DOI to cite this document:
10.5283/epub.40507
Setzer, Markus
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Jan 2020 06:27


Abstract (English)

Mutations of LMX1B lead to the hereditary disease NPS, which is associated with renal symptoms (Witzgall, 2017). Within the kidney, the transcription factor LMX1B is exclusively expressed in podocytes and plays an essential role in the maturation and maintenance of the cell. Previous studies revealed not only the putative Lmx1b target genes Abra, Arl4c and Sm22, but also evidence of an impact of ...

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Translation of the abstract (German)

Mutationen des Transkriptionsfaktors LMX1B verursachen die Erbkrankheit Nagel-Patella-Syndrom, die bei einigen Patienten zu Nierenschäden führt (Witzgall, 2017). Innerhalb der Niere wird LMX1B ausschließlich in Podozyten exprimiert und spielt dabei eine essentielle Rolle sowohl in der Zellentwicklung als auch in der Instandhaltung. Frühere Lmx1b knock-out Studien zeigten eine Dysregulation der ...

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