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Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion

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Schramm, Andrea ; Schweda, Frank ; Sequeira-Lopez, Maria Luisa S. ; Hofmann, Franz ; Sandner, Peter ; Schlossmann, Jens
Date of publication of this fulltext: 25 Jul 2019 06:16


Pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) is, in combination with diuretics, the first-choice treatment for hypertension, although 10-20% of patients do not respond adequately. Next to the RAAS, the nitric oxide/cGMP/protein kinase G (PKG) system is the second fundamental blood pressure regulator. Whether both systems influence each other is not well-studied. ...


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