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Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids

Kneuttinger, Andrea C. ; Straub, Kristina ; Bittner, Philipp ; Simeth, Nadja Anita ; Bruckmann, Astrid ; Busch, Florian ; Rajendran, Chitra ; Hupfeld, Enrico ; Wysocki, Vicki H. ; Horinek, Dominik ; König, Burkhard ; Merkl, Rainer ; Sterner, Reinhard



Abstract

Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the glutaminase subunit HisH. To control this stimulation with light, we have incorporated the photo-responsive unnatural amino acids phenylalanine-4′-azobenzene (AzoF), o-nitropiperonyl-O-tyrosine (NPY), and methyl-o-nitropiperonyllysine (mNPK) at ...

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