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Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids

Kneuttinger, Andrea C., Straub, Kristina , Bittner, Philipp, Simeth, Nadja Anita , Bruckmann, Astrid, Busch, Florian, Rajendran, Chitra, Hupfeld, Enrico, Wysocki, Vicki H. , Horinek, Dominik , König, Burkhard , Merkl, Rainer and Sterner, Reinhard (2019) Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids. Cell Chemical Biology 26.

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Abstract

Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bienzyme complex in which substrate binding to the synthase subunit HisF stimulates the glutaminase subunit HisH. To control this stimulation with light, we have incorporated the photo-responsive unnatural amino acids phenylalanine-4′-azobenzene (AzoF), o-nitropiperonyl-O-tyrosine (NPY), and methyl-o-nitropiperonyllysine (mNPK) at ...

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Item type:Article
Date:2019
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Dominik Horinek
Projects:DFG STE 891/12-1
Identification Number:
ValueType
10.1016/j.chembiol.2019.08.006DOI
31495713PubMed ID
Keywords:allostery; enzyme catalysis; photo-control; protein design; synthetic biology; unnatural amino acids
Dewey Decimal Classification:500 Science > 530 Physics
500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:40809
Owner only: item control page
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