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Modifications at Arg and Ile Give Neurotensin(8−13) Derivatives with High Stability and Retained NTS1 Receptor Affinity

Schindler, Lisa ; Bernhardt, Günther ; Keller, Max



Abstract

Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been suggested and explored as a target for tumor diagnosis and therapy. Animal model-based investigations of various radiolabeled NTS1R ligands derived from the hexapeptide neurotensin(8–13) (NT(8–13)), e.g. 68Ga- and 18F-labeled compounds for PET diagnostics, give rise to optimize such radiotracers for ...

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