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Loss-Function Learning for Digital Tissue Deconvolution

Goertler, Franziska ; Schoen, Marian ; Simeth, Jakob ; Solbrig, Stefan ; Wettig, Tilo ; Oefner, Peter J. ; Spang, Rainer ; Altenbuchinger, Michael



Abstract

The gene expression profile of a tissue averages the expression profiles of all cells in this tissue. Digital tissue deconvolution addresses the following inverse problem: given the expression profileyof a tissue, what is the cellular compositioncof that tissue? IfXis a matrix whose columns are reference profiles of individual cell types, the compositionccan be computed by minimizingfor a given ...

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