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Loss-Function Learning for Digital Tissue Deconvolution

Goertler, Franziska ; Schoen, Marian ; Simeth, Jakob ; Solbrig, Stefan ; Wettig, Tilo ; Oefner, Peter J. ; Spang, Rainer ; Altenbuchinger, Michael


The gene expression profile of a tissue averages the expression profiles of all cells in this tissue. Digital tissue deconvolution addresses the following inverse problem: given the expression profile y of a tissue, what is the cellular composition c of that tissue? If X is a matrix whose columns are reference profiles of individual cell types, the composition c can be computed by minimizing ...


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