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CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy

Bucher, Felicitas ; Walz, Johanna M. ; Bühler, Anima ; Aguilar, Edith ; Lange, Clemens ; Diaz-Aguilar, Sophia ; Martin, Gottfried ; Schlunck, Günther ; Agostini, Hansjürgen ; Friedlander, Martin ; Stahl, Andreas



Abstract

PURPOSE. Retinal vascular disease represents a major cause for vision loss in the Western world. Recent research has shown that neuronal and vascular damage are closely related in retinal disease. Ciliary neurotrophic factor (CNTF) is a well-studied neurotrophic factor that is currently being tested in clinical trials for the treatment of retinal degenerative diseases and macular telangiectasia. ...

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