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Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders

Dolles, Dominik ; Nimczick, Martin ; Scheiner, Matthias ; Ramler, Jacqueline ; Stadtmüller, Patricia ; Sawatzky, Edgar ; Drakopoulos, Antonios ; Sotriffer, Christoph ; Wittmann, Hans-Joachim ; Strasser, Andrea ; Decker, Michael



Abstract

A pharmacophore model for butyrylcholinesterase (BChE) inhibitors was applied to a human cannabinoid subtype 2 receptor (hCB(2)R) agonist and verified it as a first-generation lead for respective dual-acting compounds. The design, synthesis, and pharmacological evaluation of various derivatives led to the identification of aminobenzimidazoles as second-generation leads with micro-or ...

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