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Pharmacokinetic Drug-Drug Interactions of Mood Stabilizers and Risperidone in Patients Under Combined Treatment

Schoretsanitis, Georgios ; Haen, Ekkehard ; Gründer, Gerhard ; Stegmann, Benedikt ; Schruers, Koen R. J. ; Hiemke, Christoph ; Lammertz, Sarah E. ; Paulzen, Michael



Abstract

Background: The combination of anticonvulsant mood stabilizers with antipsychotic drugs may lead to clinically relevant drug-drug interactions. The objective of the study was to identify pharmacokinetic interactions of different mood stabilizers on the metabolism of risperidone (RIS) under natural conditions. Methods: A large therapeutic drug monitoring database containing plasma concentrations ...

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