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UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors

Bartole, Edith ; Grätz, Lukas ; Littmann, Timo ; Wifling, David ; Seibel, Ulla ; Buschauer, Armin ; Bernhardt, Günther



Abstract

Comprehensively characterized fluorescent probes for the histamine H-3 receptor (H3R) and especially for the H4R orthologs [e.g., human (h) and mouse (m)] are highly needed as versatile complementary tools to radioligands. In view of fluorescent probes for BRET-based binding studies and for localizing the H4R in live cells, we synthesized and biologically characterized Py-5-labeled histamine ...

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