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Conserved genomic neighborhood is a strong but no perfect indicator for a direct interaction of microbial gene products

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Esch, Robert ; Merkl, Rainer
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Jan 2021 15:13


Background The order of genes in bacterial genomes is not random; for example, the products of genes belonging to an operon work together in the same pathway. The cotranslational assembly of protein complexes is deemed to conserve genomic neighborhoods even stronger than a common function. This is why a conserved genomic neighborhood can be utilized to predict, whether gene products form protein ...


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