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Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity

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Antoni, Frauke ; Bernhardt, Günther
Date of publication of this fulltext: 07 Jan 2021 06:54

This publication is part of the DEAL contract with Wiley.


In previous studies, we demonstrated that esters of bendamustine containing a basic moiety are far more cytotoxic anticancer agents than their parent compound and that the substitution of the labile ester moiety by a branched ester or an amide markedly increases stability in the blood plasma. In the current study, we showed that this substitution was bioisosteric. Aiming at increased ...


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