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Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity

URN to cite this document:
urn:nbn:de:bvb:355-epub-443645
DOI to cite this document:
10.5283/epub.44364
Antoni, Frauke ; Bernhardt, Günther
Date of publication of this fulltext: 07 Jan 2021 06:54

This publication is part of the DEAL contract with Wiley.


Abstract

In previous studies, we demonstrated that esters of bendamustine containing a basic moiety are far more cytotoxic anticancer agents than their parent compound and that the substitution of the labile ester moiety by a branched ester or an amide markedly increases stability in the blood plasma. In the current study, we showed that this substitution was bioisosteric. Aiming at increased ...

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