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Design, Synthesis and Characterization of ABCG2 Inhibitors with a Focus on Water Solubility and Stability in Plasma

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Antoni, Frauke
Date of publication of this fulltext: 14 Jan 2021 08:57

Abstract (English)

ATP-binding cassette (ABC) transporters are gatekeepers at all major tissue barriers, e.g. the intestinal barrier or the blood-brain barrier (BBB). On one hand, these proteins extrude endogenous substrates and on the other hand, they protect cells against the entry of numerous xenobiotics, including a variety of drugs such as anticancer agents or neuropharmaceuticals. The three main drug ...


Translation of the abstract (German)

ATP-binding cassette (ABC) Transporter sind Pförtner an allen wichtigen Gewebebarrieren, wie der Darmbarriere oder der Blut-Hirn-Schranke (BHS). Einerseits extrudieren diese Proteine endogene Substrate, andererseits schützen sie Zellen vor zahlreichen Xenobiotika, darunter etliche Arzneistoffe wie Krebsmedikamente oder Neuropharmaka. Die drei wichtigsten Arzneistofftransporter sind ABCB1, ABCC1 ...


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