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Histamine H2 receptor radioligands: triumphs and challenges

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Pockes, Steffen ; Tropmann, Katharina
Date of publication of this fulltext: 19 Aug 2021 12:11


Since the discovery of the histamine H-2 receptor (H2R), radioligands were among the most powerful tools to investigate its role and function. Initially, radiolabeling was used to investigate human and rodent tissues regarding their receptor expression. Later, radioligands gained increasing significance as pharmacological tools in in vitro assays. Although tritium-labeling was mainly used for ...


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