Histamine H2 receptor radioligands: triumphs and challenges

URN to cite this document:: urn:nbn:de:bvb:355-epub-463410
DOI to cite this document:: 10.5283/epub.46341

Pockes, Steffen

; Tropmann, Katharina

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Date of publication of this fulltext: 19 Aug 2021 12:11

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Abstract

Since the discovery of the histamine H2 receptor (H2R), radioligands were among the most powerful tools to investigate its role and function. Initially, radiolabeling was used to investigate human and rodent tissues regarding their receptor expression. Later, radioligands gained increasing significance as pharmacological tools in in vitro assays. Although tritium-labeling was mainly used for this ...