Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-464432
DOI to cite this document:: 10.5283/epub.46443

Fazzini, Federica ; Lamina, Claudia ; Raschenberger, Julia ; Schultheiss, Ulla T. ; Kotsis, Fruzsina ; Schönherr, Sebastian ; Weissensteiner, Hansi ; Forer, Lukas ; Steinbrenner, Inga ; Meiselbach, Heike ; Bärthlein, Barbara ; Wanner, Christoph ; Eckardt, Kai-Uwe ; Köttgen, Anna ; Kronenberg, Florian ; Eckardt, Kai-Uwe ; Meiselbach, Heike ; Schneider, Markus ; Dienemann, Thomas ; Prokosch, Hans-Ulrich ; Bärthlein, Barbara ; Beck, Andreas ; Ganslandt, Thomas ; Reis, André ; Ekici, Arif B. ; Avendaño, Susanne ; Becker-Grosspitsch, Dinah ; Alberth-Schmidt, Ulrike ; Hausknecht, Birgit ; Zitzmann, Rita ; Weigel, Anke ; Walz, Gerd ; Köttgen, Anna ; Schultheiß, Ulla T. ; Kotsis, Fruzsina ; Meder, Simone ; Mitsch, Erna ; Reinhard, Ursula ; Floege, Jürgen ; Schlieper, Georg ; Saritas, Turgay ; Ernst, Sabine ; Beaujean, Nicole ; Schaeffner, Elke ; Baid-Agrawal, Seema ; Theisen, Kerstin ; Haller, Hermann ; Menne, Jan ; Zeier, Martin ; Sommerer, Claudia ; Woitke, Rebecca ; Wolf, Gunter ; Busch, Martin ; Fuß, Rainer ; Sitter, Thomas ; Blank, Claudia ; Wanner, Christoph ; Krane, Vera ; Börner-Klein, Antje ; Bauer, Britta ; Kronenberg, Florian ; Raschenberger, Julia ; Kollerits, Barbara ; Forer, Lukas ; Schönherr, Sebastian ; Weissensteiner, Hansi ; Oefner, Peter ; Gronwald, Wolfram ; Zacharias, Helena ; Schmid, Matthias ; Nadal, Jennifer

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Abstract

Telomere length is known to be inversely associated with aging and has been proposed as a marker for aging-related diseases. Telomere attrition can be accelerated by oxidative stress and inflammation, both commonly present in patients with chronic kidney disease. Here, we investigated whether relative telomere length is associated with mortality in a large cohort of patients with chronic kidney ...