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Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

Kovač, Kristina ; Sauer, Anja ; Mačinković, Igor ; Awe, Stephan ; Finkernagel, Florian ; Hoffmeister, Helen ; Fuchs, Andreas ; Müller, Rolf ; Rathke, Christina ; Längst, Gernot ; Brehm, Alexander


ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly conserved Drosophila homologue of CHD4. Mutations from different patients have surprisingly diverse ...


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