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Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine

Kowalewski, Christoph ; Haen, Ekkehard ; Hiemke, Christoph ; Ridders, Florian ; Endres, Katharina ; Gründer, Gerhard ; Paulzen, Michael ; Schoretsanitis, Georgios


Objective The aim of this study was to ensure patients' safety and to enhance treatment efficacy, knowledge about pharmacokinetic interactions even in complex clinical situations of polypharmacy is invaluable. This study is to uncover the potential of pharmacokinetic interactions between venlafaxine and trimipramine in a naturalistic sample. Methods Out of a therapeutic drug monitoring database ...


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