Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process

Schlemmer, Richard ; Spruß, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut

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Details

Item type:	Article
Date:	2000
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:	SFB 234
Identification Number:	Value Type 10783521 PubMed ID 10.1002/(SICI)1521-4184(200002)333:2/3<69::AID-ARDP69>3.0.CO;2-D DOI
Classification:	Notation Type Animals MESH Female MESH Immunologic Factors/pharmacology MESH Mammary Neoplasms, Experimental/drug therapy MESH Mice MESH Neoplasm Transplantation MESH Neoplasms, Hormone-Dependent/drug therapy MESH Organoplatinum Compounds/pharmacology MESH
Dewey Decimal Classification:	500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	4841

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Abstract

The MXT-M-3.2 breast cancer implanted into female B6D2F1 mice accelerates the growth of an identical second tumor. This process is inhibited by [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II). The possible modes of action of this compound as a biological response modifier are discussed.

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