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Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors

Heider, Fabian ; Ansideri, Francesco ; Tesch, Roberta ; Pantsar, Tatu ; Haun, Urs ; Döring, Eva ; Kudolo, Mark ; Poso, Antti ; Albrecht, Wolfgang ; Laufer, Stefan A. ; Koch, Pierre


Compounds simultaneously inhibiting two targets that are involved in the progression of the same complex disease may exhibit additive or even synergistic therapeutic effects. Here we unveil 2,4,5-trisubstituted imidazoles as dual inhibitors of p38 alpha mitogen-activated protein kinase and glycogen synthase kinase 3 beta (GSK3 beta). Both enzymes are potential therapeutic targets for ...


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