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Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands

Łażewska, Dorota ; Mogilski, Szczepan ; Hagenow, Stefanie ; Kuder, Kamil ; Głuch-Lutwin, Monika ; Siwek, Agata ; Więcek, Małgorzata ; Kaleta, Maria ; Seibel, Ulla ; Buschauer, Armin ; Filipek, Barbara ; Stark, Holger ; Kieć-Kononowicz, Katarzyna



Abstract

This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines. New compounds were synthesized and their affinities for human histamine H-4 receptor (hH(4)R) were evaluated. Among them, 4-(cyclohexylmethyl)-6-(4-methylpiperazin-1-yl)1,3,5- triazin-2-amine (14) exhibited hH(4)R affinity with a K-i of 160 nM and ...

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