Go to content
UR Home

Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands

Łażewska, Dorota ; Mogilski, Szczepan ; Hagenow, Stefanie ; Kuder, Kamil ; Głuch-Lutwin, Monika ; Siwek, Agata ; Więcek, Małgorzata ; Kaleta, Maria ; Seibel, Ulla ; Buschauer, Armin ; Filipek, Barbara ; Stark, Holger ; Kieć-Kononowicz, Katarzyna


This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines. New compounds were synthesized and their affinities for human histamine H-4 receptor (hH(4)R) were evaluated. Among them, 4-(cyclohexylmethyl)-6-(4-methylpiperazin-1-yl)1,3,5- triazin-2-amine (14) exhibited hH(4)R affinity with a K-i of 160 nM and ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: daten@ur.de
0941 943 -5707

Contact persons