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Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties

Agnetta, Luca ; Bermudez, Marcel ; Riefolo, Fabio ; Matera, Carlo ; Claro, Enrique ; Messerer, Regina ; Littmann, Timo ; Wolber, Gerhard ; Holzgrabe, Ulrike ; Decker, Michael



Zusammenfassung

Red-shifted azobenzene scaffolds have emerged as useful molecular photoswitches to expand potential applications of photopharmacological tool compounds. As one of them, tetra-ortho-fluoro azobenzene is well compatible for the design of visible-light-responsive systems, providing stable and bidirectional photoconversions and tissue-compatible characteristics. Using the unsubstituted azobenzene ...

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