| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Sleep Medicine | ||||
| Publisher: | Elsevier | ||||
| Place of Publication: | AMSTERDAM | ||||
| Volume: | 54 | ||||
| Page Range: | pp. 205-212 | ||||
| Date: | 2019 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Institut für Epidemiologie und Präventivmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Identification Number: |
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| Keywords: | REPORTED SLEEP DURATION; GLOMERULAR-FILTRATION-RATE; RISK-FACTOR; POPULATION; PREVALENCE; ADULTS; APNEALINK(TM); HYPERTENSION; PROTEINURIA; DISORDERS; Diabetes; Sleep duration; Napping; Kidney disease; eGFR; UACR | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 49037 |
Web of ScienceAbstract
Background: Diabetes-associated Kidney Disease (DKD) is a common comorbidity in patients with type 2 diabetes. The present study investigates whether daytime sleeping duration in patients, ill with type 2 diabetes, is associated with DKD. Methods: A total of 733 outpatients of the cross-sectional baseline survey of the DIACORE study were analyzed with respect to their self-reported daytime ...
Abstract
Background: Diabetes-associated Kidney Disease (DKD) is a common comorbidity in patients with type 2 diabetes. The present study investigates whether daytime sleeping duration in patients, ill with type 2 diabetes, is associated with DKD. Methods: A total of 733 outpatients of the cross-sectional baseline survey of the DIACORE study were analyzed with respect to their self-reported daytime sleeping duration, assessed by a standardized questionnaire. DKD was defined as eGFR <60 ml/min/1.73 m(2) and/or urinary albumin-to-creatinine-ratio (UACR) > 30 mg/g. Results: Mean daytime sleeping duration was 17 +/- 27 min. With increasing daytime sleeping duration a statistically significant decrease in eGFR (p = 0.002) and increase in UACR (p < 0.001) were found, respectively. Prevalence of DKD was significantly higher in patients with longer daytime sleeping duration (31% in patients not napping, 40% in patients napping less than 30 min, 47% in patients napping 30-60 min, 56% in patients napping 60 min or more; p = 0.001). After accounting for known modulators (Age, sex, BMI, waist-hip-ratio, systolic and diastolic blood pressure, physical activity, diabetes duration, HbA1c, homeostasis model assessment (HOMA-Index), nighttime sleeping duration, apnea-hypopnea-index (AHI), Epworth Sleepiness Scale (ESS)), longer daytime sleeping duration was significantly associated with impaired eGFR [B (95% CI) = -0.05 (-0.09; 0.00), p = 0.044] and increased UACR [B (95% CI) = 0.01 (0.01; 0.02), p < 0.001], respectively. Conclusion: Increased daytime sleeping duration is significantly associated with reduced eGFR and higher UACR, independent of known modulators of DKD. The direction of this relationship remains unclear. (c) 2018 Elsevier B.V. All rights reserved.
Metadata last modified: 03 Sep 2021 10:05
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