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IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension

Biswas, Siladitta ; Kojonazarov, Baktybek ; Hadzic, Stefan ; Majer, Michael ; Bajraktari, Ganimete ; Novoyatleva, Tatyana ; Ghofrani, Hossein Ardeschir ; Grimminger, Friedrich ; Seeger, Werner ; Weissmann, Norbert ; Schlossmann, Jens ; Schermuly, Ralph Theo


PKGs are serine/threonine kinases. PKG1 has two isoforms-PKG1 alpha and beta. Inositol trisphosphate receptor (IP3R)-associated cGMP-kinase substrate 1 (IRAG1) is a substrate for PKG1 beta. IRAG1 is also known to further interact with IP3RI, which mediates intracellular Ca2+ release. However, the role of IRAG1 in PH is not known. Herein, WT and IRAG1 KO mice were kept under normoxic or hypoxic ...


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