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Fluorescent H2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications

Biselli, Sabrina ; Alencastre, Inês ; Tropmann, Katharina ; Erdmann, Daniela ; Chen, Mengya ; Littmann, Timo ; Maia, André F. ; Gomez-Lazaro, Maria ; Tanaka, Miho ; Ozawa, Takeaki ; Keller, Max ; Lamghari, Meriem ; Buschauer, Armin ; Bernhardt, Günther



Abstract

Fluorescence labeled ligands have been gaining importance as molecular tools, enabling receptor-ligand-binding studies by various fluorescence-based techniques. Aiming at red-emitting fluorescent ligands for the hH(2)R, a series of squaramides labeled with pyridinium or cyanine fluorophores (19-27) was synthesized and characterized. The highest hH(2)R affinities in radioligand competition binding ...

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