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Design of dye and superparamagnetic iron oxide nanoparticle loaded lipid nanocapsules with dual detectability in vitro and in vivo

Bohley, Marilena S. ; Birch, Emily ; Baumann, Felix J. ; Dillinger, Andrea E. ; Tamm, Ernst R. ; Goepferich, Achim M.



Abstract

Lipid nanocapsules are treasured nanoparticulate systems, although they lack detectability in biological environments. To overcome this, we designed LNCs loaded simultaneously with fluorescent dye and superparamagnetic iron oxide nanoparticles (Dual LNCs). The introduction of both labels did not alter nanoparticle characteristics such as size (50 nm), size distribution (polydispersity index < ...

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