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Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity

Gruber, Corinna G. ; Pegoli, Andrea ; Müller, Christoph ; Grätz, Lukas ; She, Xueke ; Keller, Max


A series of fluorescent dibenzodiazepinone-type muscarinic acetylcholine M(2)receptor (M2R) ligands was synthesized using various fluorescent dyes (5-TAMRA,lambda(ex)/lambda(em)approximate to 547/576 nm; BODIPY 630/650,lambda(ex)/lambda(em)approximate to 625/640 nm; pyridinium dye Py-1,lambda(ex)/lambda(em)approximate to 611/665 nm and pyridinium dye Py-5,lambda(ex)/lambda(em)approximate to ...


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