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Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction

Schupfner, Michael ; Straub, Kristina ; Busch, Florian ; Merkl, Rainer ; Sterner, Reinhard


Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate indole and the mutual activation of the alpha-subunit TrpA and the beta-subunit TrpB via a complex allosteric network. We have analyzed this allosteric network by means of ancestral sequence reconstruction (ASR), which is an in silico method to resurrect ...


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