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Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications

DOI to cite this document:
Schilling, Hannah-Lou ; Glehr, Gunther ; Kapinsky, Michael ; Ahrens, Norbert ; Riquelme, Paloma ; Cordero, Laura ; Bitterer, Florian ; Schlitt, Hans J. ; Geissler, Edward K. ; Haferkamp, Sebastian ; Hutchinson, James A. ; Kronenberg, Katharina
[img]License: Creative Commons Attribution No Derivatives 4.0
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Date of publication of this fulltext: 27 Jan 2022 16:57


Treatment of advanced melanoma with combined immune checkpoint inhibitor (ICI) therapy is complicated in up to 50% of cases by immune-related adverse events (irAE) that commonly include hepatitis, colitis and skin reactions. We previously reported that pre-therapy expansion of cytomegalovirus (CMV)-reactive CD4(+) effector memory T cells (T-EM) predicts ICI-related hepatitis in a subset of ...


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