Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases

URN to cite this document:: urn:nbn:de:bvb:355-epub-522799
DOI to cite this document:: 10.5283/epub.52279

Li, Yong ; Cheng, Yurong ; Consolato, Francesco

; Schiano, Guglielmo

; Chong, Michael R.

; Pietzner, Maik

; Nguyen, Ngoc Quynh H. ; Scherer, Nora ; Biggs, Mary L. ; Kleber, Marcus E.

; Haug, Stefan

; Göçmen, Burulça ; Pigeyre, Marie ; Sekula, Peggy

; Steinbrenner, Inga ; Schlosser, Pascal

; Joseph, Christina B. ; Brody, Jennifer A. ; Grams, Morgan E. ; Hayward, Caroline ; Schultheiss, Ulla T. ; Krämer, Bernhard K. ; Kronenberg, Florian ; Peters, Annette

; Seissler, Jochen ; Steubl, Dominik ; Then, Cornelia ; Wuttke, Matthias ; März, Winfried ; Eckardt, Kai-Uwe ; Gieger, Christian ; Boerwinkle, Eric ; Psaty, Bruce M. ; Coresh, Josef ; Oefner, Peter J. ; Pare, Guillaume ; Langenberg, Claudia

; Scherberich, Jürgen E. ; Yu, Bing ; Akilesh, Shreeram ; Devuyst, Olivier

; Rampoldi, Luca

; Köttgen, Anna

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Date of publication of this fulltext: 16 May 2022 06:12

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Abstract

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and pathogen defense. To gain insights into potential systemic roles, we performed genome-wide screens of circulating uromodulin using complementary antibody-based and aptamer-based ...