Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors

URN to cite this document:: urn:nbn:de:bvb:355-epub-527017
DOI to cite this document:: 10.5283/epub.52701

Schmid, Verena ; Wurzel, Alexander

; Wetzel, Christian H.

; Plössl, Karolina ; Bruckmann, Astrid ; Luckner, Patricia ; Weber, Bernhard H. F. ; Friedrich, Ulrike

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Aug 2022 12:52

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Abstract

The RS1 gene on Xp 22.13 encodes retinoschisin which is known to directly interact with the retinal Na/K-ATPase at the photoreceptor inner segments. Pathologic mutations in RS1 cause X-linked juvenile retinoschisis (XLRS), a hereditary retinal dystrophy in young males. To further delineate the retinoschisin-Na/K-ATPase complex, co-immunoprecipitation was performed with porcine and murine retinal ...