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Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors

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Schmid, Verena ; Wurzel, Alexander ; Wetzel, Christian H. ; Plössl, Karolina ; Bruckmann, Astrid ; Luckner, Patricia ; Weber, Bernhard H. F. ; Friedrich, Ulrike
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Aug 2022 12:52

This publication is part of the DEAL contract with Springer.


The RS1 gene on Xp 22.13 encodes retinoschisin which is known to directly interact with the retinal Na/K-ATPase at the photoreceptor inner segments. Pathologic mutations in RS1 cause X-linked juvenile retinoschisis (XLRS), a hereditary retinal dystrophy in young males. To further delineate the retinoschisin-Na/K-ATPase complex, co-immunoprecipitation was performed with porcine and murine retinal ...


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