The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis

URN to cite this document:: urn:nbn:de:bvb:355-epub-527500
DOI to cite this document:: 10.5283/epub.52750

Drexler, Konstantin ; Schwertner, Barbara ; Haerteis, Silke ; Aung, Thiha ; Berneburg, Mark ; Geissler, Edward K. ; Mycielska, Maria E.

; Haferkamp, Sebastian

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Aug 2022 14:04

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Abstract

Simple Summary Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer. Despite important progress, overall understanding of the events that drive MCC carcinogenesis remains incomplete. We discovered that the plasma membrane citrate transporter (pmCiC) is upregulated in Merkel cell carcinoma cell lines. Cancer cells import extracellular citrate via pmCiC to support their ...