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The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis

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Drexler, Konstantin ; Schwertner, Barbara ; Haerteis, Silke ; Aung, Thiha ; Berneburg, Mark ; Geissler, Edward K. ; Mycielska, Maria E. ; Haferkamp, Sebastian
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Date of publication of this fulltext: 16 Aug 2022 14:04


Merkel cell carcinoma (MCC) is a rare but highly aggressive tumor of the skin with a poor prognosis. The factors driving this cancer must be better understood in order to discover novel targets for more effective therapies. In the search for targets, we followed our interest in citrate as a central and critical metabolite linked to fatty acid synthesis in cancer development. A key to citrate ...


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