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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-528607
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.52860
Zusammenfassung
Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we present the purification of human Pol I from cells carrying a genomic GFP fusion on the largest subunit allowing the structural and functional analysis of the enzyme across species. In contrast to yeast, human Pol I carries ...
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