CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry

URN to cite this document:: urn:nbn:de:bvb:355-epub-528936
DOI to cite this document:: 10.5283/epub.52893

Heinl, Elena-Sofia ; Lorenz, Sebastian ; Schmidt, Barbara

; Laqtom, Nouf Nasser M. ; Mazzulli, Joseph R. ; Francelle, Laetitia

; Yu, Timothy W. ; Greenberg, Benjamin

; Storch, Stephan ; Tegtmeier, Ines ; Othmen, Helga ; Maurer, Katja ; Steinfurth, Malin ; Witzgall, Ralph ; Milenkovic, Vladimir M. ; Wetzel, Christian H.

; Reichold, Markus

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Date of publication of this fulltext: 20 Sep 2022 06:13

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Abstract

The SARS-CoV-2 virus has triggered a worldwide pandemic. According to the BioGrid database, CLN7 (MFSD8) is thought to interact with several viral pro-teins. The aim of this work was to investigate a possible involvement of CLN7 in the infection process. Experiments on a CLN7-deficient HEK293T cell line ex-hibited a 90% reduced viral load compared to wild-type cells. This observation may be ...