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Cas12a is governed in its Activity and Conformational Transitions by the Two Interplaying Key Elements Helix 1 and Bridge Helix

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Wörle, Elisabeth Johanna Viera
Date of publication of this fulltext: 09 Dec 2022 09:29

Abstract (English)

The CRISPR-Cas system (clustered regularly interspaced short palindromic repeats and CRISPR associated proteins) is a widespread and versatile prokaryotic immune system, that evolved to sequence-dependently recognize and cleave foreign nucleic acids. The single-effector nuclease of the type V-A CRISPR-Cas system, Cas12a, binds and cleaves double-stranded target DNA with the aid of a CRISPR-RNA ...


Translation of the abstract (English)

Das CRISPR-Cas-System (clustered regularly interspaced short palindromic repeats und CRISPR associated proteins) ist ein vielseitiges und weit verbreitetes prokaryotisches Abwehrsystem, das fremde Nukleinsäuren sequenzabhängig erkennt und spaltet. Die eigenständige Effektornuklease des CRISPR-Cas-Systems V-A, Cas12a, bindet und spaltet doppelsträngige Ziel-DNA mit Hilfe einer CRISPR-RNA (crRNA). ...


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