Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine

URN to cite this document:: urn:nbn:de:bvb:355-epub-543660
DOI to cite this document:: 10.5283/epub.54366

Schlosser, Pascal ; Scherer, Nora ; Grundner-Culemann, Franziska ; Monteiro-Martins, Sara ; Haug, Stefan ; Steinbrenner, Inga ; Uluvar, Burulça ; Wuttke, Matthias ; Cheng, Yurong ; Ekici, Arif B. ; Gyimesi, Gergely ; Karoly, Edward D. ; Kotsis, Fruzsina ; Mielke, Johanna ; Gomez, Maria F. ; Yu, Bing ; Grams, Morgan E. ; Coresh, Josef ; Boerwinkle, Eric ; Köttgen, Michael ; Kronenberg, Florian ; Meiselbach, Heike ; Mohney, Robert P. ; Akilesh, Shreeram ; Schmidts, Miriam ; Hediger, Matthias A. ; Schultheiss, Ulla T. ; Eckardt, Kai-Uwe ; Oefner, Peter J. ; Sekula, Peggy ; Li, Yong ; Köttgen, Anna

License: Creative Commons Attribution 4.0
PDF - Published Version
(10MB)

Date of publication of this fulltext: 15 Jun 2023 06:50

Alternative links to fulltext:Pubmed DOI Publisher

Details

Preview

Export bibliographical data

Abstract

The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been ...