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Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

Taha, H. M. ; Schmidt, J. ; Göttle, M. ; Suryanarayana, S. ; Shen, Y. ; Tang, W.-J. ; Gille, A. ; Geduhn, Jens ; König, Burkhard ; Dove, Stefan ; Seifert, Roland


Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional antibiotic treatment is ineffective against either toxemia or antibiotic-resistant strains. Thus, more effective drugs for anthrax treatment are ...


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