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Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design

Hertle, Regina ; Nazet, Julian ; Semmelmann, Florian ; Schlee, Sandra ; Funke, Franziska ; Merkl, Rainer ; Sterner, Reinhard


The formation of specific protein complexes in a cell is a non-trivial problem given the co-existence of thousands of different polypeptide chains. A particularly difficult case are two glutamine amidotransferase complexes (anthranilate synthase [AS] and aminodeoxychorismate synthase [ADCS]), which are composed of homologous pairs of synthase and glutaminase subunits. We have attempted to ...


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