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Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation

Rösch, G. ; El Bagdadi, K. ; Muschter, D. ; Taheri, S. ; Dorn, C. ; Meurer, A. ; Straub, R.H. ; Zaucke, F. ; Schilling, A.F. ; Grässel, S. ; Jenei-Lanzl, Z.



Abstract

Objective: Osteoarthritis (OA) pathogenesis involves the interaction of articular cartilage with surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) sympathetic nerve fibers suggesting a role of the sympathetic nervous system (SNS) during OA progression. We analyzed the effects of sympathectomy (Syx) in a murine OA model. Methods: Peripheral Syx was generated by ...

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