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Integration of high-throughput proteomic data and complementary omics layers with PriOmics

Kosch, Robin ; Limm, Katharina ; Staiger, Annette M. ; Kurz, Nadine S. ; Seifert, Nicole ; Oláh, Bence ; Solbrig, Stefan ; Poeschel, Viola ; Held, Gerhard ; Ziepert, Marita ; Schmitz, Norbert ; Chteinberg, Emil ; Siebert, Reiner ; Spang, Rainer ; Zacharias, Helena U. ; Ott, German ; Oefner, Peter J. ; Altenbuchinger, Michael



Abstract

High-throughput bottom-up proteomics data cover 1,000s of proteins and related co- and post-translational modifications (CTMs/PTMs). Yet, it remains an open question how to holistically explore such data and their relationship to complementary omics/phenotypical information. Graphical models are particularly suited to study molecular networks and underlying regulatory mechanisms, as they can ...

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