Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.

Mahboobi, Siavosh, Dove, Stefan, Sellmer, Andreas, Winkler, Matthias, Eichhorn, Emerich, Pongratz, Herwig, Ciossek, Thomas, Baer, Thomas, Maier, Thomas and Beckers, Thomas (2009) Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases. Journal of medicinal chemistry 52 (8), pp. 2265-79.

Date of publication of this fulltext: 05 Aug 2009 13:58
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Involved Institutions

• Chemistry and Pharmacy > Institute of Pharmacy

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• Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)

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Details

Item type	Article
Journal or Publication Title	Journal of medicinal chemistry
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
Volume:	52
Number of Issue or Book Chapter:	8
Page Range:	pp. 2265-79
Date	2009
Institutions	Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number	Value Type 19301902 PubMed ID 10.1021/jm800988r DOI
Classification	Notation Type Acetylation MESH Benzamides/chemical synthesis MESH Cell Line, Tumor MESH Cell Proliferation/drug effects MESH Drug Screening Assays, Antitumor MESH Histone Deacetylases/antagonists & inhibitors MESH Histones/metabolism MESH Humans MESH Models, Molecular MESH Mutation MESH Phthalic Acids/chemical synthesis MESH Piperazines/chemical synthesis MESH Protein-Tyrosine Kinases/antagonists & inhibitors MESH Pyrimidines/chemical synthesis MESH Receptor, Platelet-Derived Growth Factor beta/antagonists & inhibitors MESH Stereoisomerism MESH Structure-Activity Relationship MESH Thiazoles/chemical synthesis MESH Thiophenes/chemical synthesis MESH
Keywords	SUBEROYLANILIDE HYDROXAMIC ACID; PHENYLAMINO-PYRIMIDINE PAP; CHRONIC MYELOID-LEUKEMIA; CRYSTAL-STRUCTURE; HDAC INHIBITORS; AURORA KINASES; CELL-LINES; RESISTANCE; CANCER; STI571;
Dewey Decimal Classification	600 Technology > 615 Pharmacy 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine
Status	Published
Refereed	Yes, this version has been refereed
Created at the University of Regensburg	Partially
Item ID	8551

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