Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.

Article

Mahboobi, Siavosh, Dove, Stefan, Sellmer, Andreas, Winkler, Matthias, Eichhorn, Emerich, Pongratz, Herwig, Ciossek, Thomas, Baer, Thomas, Maier, Thomas and Beckers, Thomas (2009) Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases. Journal of medicinal chemistry 52 (8), pp. 2265-79.

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Involved Institutions

• Chemistry and Pharmacy > Institute of Pharmacy

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• Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)

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Details

Item type	Article
Journal or Publication Title	Journal of medicinal chemistry
Publisher	AMER CHEMICAL SOC
Place of Publication	WASHINGTON
Volume	52
Number of Issue or Book Chapter	8
Page Range	pp. 2265-79
Date	2009
Date of publication	05 Aug 2009 13:58
Institutions	Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number	Value Type 19301902 PubMed ID 10.1021/jm800988r DOI
Classification	Notation Type Acetylation MESH Benzamides/chemical synthesis MESH Cell Line, Tumor MESH Cell Proliferation/drug effects MESH Drug Screening Assays, Antitumor MESH Histone Deacetylases/antagonists & inhibitors MESH Histones/metabolism MESH Humans MESH Models, Molecular MESH Mutation MESH Phthalic Acids/chemical synthesis MESH Piperazines/chemical synthesis MESH Protein-Tyrosine Kinases/antagonists & inhibitors MESH Pyrimidines/chemical synthesis MESH Receptor, Platelet-Derived Growth Factor beta/antagonists & inhibitors MESH Stereoisomerism MESH Structure-Activity Relationship MESH Thiazoles/chemical synthesis MESH Thiophenes/chemical synthesis MESH
Keywords	SUBEROYLANILIDE HYDROXAMIC ACID; PHENYLAMINO-PYRIMIDINE PAP; CHRONIC MYELOID-LEUKEMIA; CRYSTAL-STRUCTURE; HDAC INHIBITORS; AURORA KINASES; CELL-LINES; RESISTANCE; CANCER; STI571;
Dewey Decimal Classification	600 Technology > 615 Pharmacy 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine
Status	Published
Refereed	Yes, this version has been refereed
Created at the University of Regensburg	Partially
Item ID	8551

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