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Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells

Seifert, Roland and Jungblut, P. and Schultz, Günter (1989) Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells. Biochemical and biophysical research communications 161 (3), pp. 1109-1117.

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Abstract

Activation of NADPH oxidase in undifferentiated HL-60 leukemic cells and in HL-60 cells differentiated along the myeloid pathway with dibutyryl cyclic AMP (dbcAMP) or dimethyl sulfoxide (Me2SO) was studied. Upon stimulation with a calcium ionophore, a phorbol ester, arachidonic acid or gamma-hexachlorocyclohexane, Me2SO-differentiated HL-60 cells generated superoxide (O2-) at higher rates than ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2472788PubMed ID
Classification:
NotationType
Arachidonic AcidMESH
Arachidonic Acids/pharmacologyMESH
Bucladesine/pharmacologyMESH
Calcimycin/pharmacologyMESH
Cell Differentiation/drug effectsMESH
Cell LineMESH
Cytosol/physiologyMESH
Dimethyl Sulfoxide/pharmacologyMESH
Enzyme ActivationMESH
Guanosine 5'-O-(3-Thiotriphosphate)MESH
Guanosine Triphosphate/pharmacologyMESH
HumansMESH
KineticsMESH
Leukemia, Promyelocytic, AcuteMESH
Lindane/pharmacologyMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
NADH, NADPH Oxidoreductases/metabolismMESH
NADPH OxidaseMESH
Superoxides/metabolismMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Thionucleotides/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 13:31
Last Modified:13 Mar 2014 18:29
Item ID:23257
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